Noboru Uchide* and Hiroo Toyoda

Molecules. 2011 Mar; 16(3): 2032–2052.

Published online 2011 Feb 28. doi: 10.3390/molecules23100000

Ascorbic acid (19, Figure 4) scavenges superoxide anion [78]. Ascorbic acid inhibited the proliferation of influenza virus in cell cultures [79]. Dehydroascorbic acid, an oxidized form of ascorbic acid without reducing ability, showed much stronger antiviral activity than that of ascorbic acid, indicating that the antiviral activity of ascorbic acid is due to factors other than antioxidant mechanism [80]. In a controlled trial of 226 patients with influenza A, 114 patients received vitamin C 300 mg/day, and 112 patients served as controls; outcomes measured were development of pneumonia and duration of hospital stay. Pneumonia was reported in two subjects in the treatment group and 10 in the control group, and hospital stays for influenza or related complications averaged nine days in the vitamin C group and 12 days in the control group [81]. Therefore it has been considered that combined inhalation and oral supplementation of ascorbic acid may prevent influenza virus infection [82].


Can Fam Physician

 2011 Jan;57(1):31-6.